Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock.

ABSTRACT:

Introduction

We sought to compare the outcomes of patients with cryptic versus overt shock treated with an emergency department (ED) based early sepsis resuscitation protocol.

Methods

Pre-planned secondary analysis of a large, multicenter ED-based randomized controlled trial of early sepsis resuscitation. All subjects were treated with a quantitative resuscitation protocol in the ED targeting 3 physiological variables: central venous pressure, mean arterial pressure and either central venous oxygen saturation or lactate clearance. The study protocol was continued until all endpoints were achieved or a maximum of 6h. Outcomes data of patients who were enrolled with a lactate ≥ 4mmol/L and normotension (cryptic shock) were compared to those enrolled with sustained hypotension

SUBMITTER: Puskarich MA 

PROVIDER: S-EPMC3179778 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature