Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines.

ABSTRACT: A novel diastereoselective synthesis of substituted pyrrolidines has been developed. Asymmetric multicomponent reactions of optically active phenyldihydrofuran, N-tosyl imino ester, and silane reagents in a one-pot operation afforded highly substituted pyrrolidine derivatives diastereoselectively. The reaction is quite efficient and constructed up to three stereogenic centers in a single operation.

SUBMITTER: Ghosh AK 

PROVIDER: S-EPMC3179855 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature