Chikungunya triggers an autophagic process which promotes viral replication.

ABSTRACT:

Background

Chikungunya Virus (ChikV) surprised by a massive re-emerging outbreak in Indian Ocean in 2006, reaching Europe in 2007 and exhibited exceptional severe physiopathology in infants and elderly patients. In this context, it is important to analyze the innate immune host responses triggered against ChikV. Autophagy has been shown to be an important component of the innate immune response and is involved in host defense elimination of different pathogens. However, the autophagic process was recently observed to be hijacked by virus for their own replication. Here we provide the first evidence that hallmarks of autophagy are specifically found in HEK.293 infected cells and are involved in ChikV replication.

Methods

To test the capacity of ChikV to mobilize the autophagi

SUBMITTER: Krejbich-Trotot P 

PROVIDER: S-EPMC3179960 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature