DARS-RNP and QUASI-RNP: new statistical potentials for protein-RNA docking.

ABSTRACT:

Background

Protein-RNA interactions play fundamental roles in many biological processes. Understanding the molecular mechanism of protein-RNA recognition and formation of protein-RNA complexes is a major challenge in structural biology. Unfortunately, the experimental determination of protein-RNA complexes is tedious and difficult, both by X-ray crystallography and NMR. For many interacting proteins and RNAs the individual structures are available, enabling computational prediction of complex structures by computational docking. However, methods for protein-RNA docking remain scarce, in particular in comparison to the numerous methods for protein-protein docking.

Results

We developed two medium-resolution, knowledge-based potentials for scoring protein-RNA models obtained by

SUBMITTER: Tuszynska I 

PROVIDER: S-EPMC3179970 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature