Selection of organisms for the co-evolution-based study of protein interactions.

ABSTRACT:

Background

The prediction and study of protein interactions and functional relationships based on similarity of phylogenetic trees, exemplified by the mirrortree and related methodologies, is being widely used. Although dependence between the performance of these methods and the set of organisms used to build the trees was suspected, so far nobody assessed it in an exhaustive way, and, in general, previous works used as many organisms as possible. In this work we asses the effect of using different sets of organism (chosen according with various phylogenetic criteria) on the performance of this methodology in detecting protein interactions of different nature.

Results

We show that the performance of three mirrortree-related methodologies depends on the set of organisms used

SUBMITTER: Herman D 

PROVIDER: S-EPMC3179974 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature