Thawing Frozen Robust Multi-array Analysis (fRMA).

ABSTRACT:

Background

A novel method of microarray preprocessing--Frozen Robust Multi-array Analysis (fRMA)--has recently been developed. This algorithm allows the user to preprocess arrays individually while retaining the advantages of multi-array preprocessing methods. The frozen parameter estimates required by this algorithm are generated using a large database of publicly available arrays. Curation of such a database and creation of the frozen parameter estimates is time-consuming; therefore, fRMA has only been implemented on the most widely used Affymetrix platforms.

Results

We present an R package, frmaTools, that allows the user to quickly create his or her own frozen parameter vectors. We describe how this package fits into a preprocessing workflow and explore the size of the t

SUBMITTER: McCall MN 

PROVIDER: S-EPMC3180392 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature