Factors that influence the response of the LysR type transcriptional regulators to aromatic compounds.

ABSTRACT:

Background

The transcriptional regulators DntR, NagR and NtdR have a high sequence identity and belong to the large family of LysR type transcriptional regulators (LTTRs). These three regulators are all involved in regulation of genes identified in pathways for degradation of aromatic compounds. They activate the transcription of these genes in the presence of an inducer, but the inducer specificity profiles are different.

Results

The results from this study show that NtdR has the broadest inducer specificity, responding to several nitro-aromatic compounds. Mutational studies of residues that differ between DntR, NagR and NtdR suggest that a number of specific residues are involved in the broader inducer specificity of NtdR when compared to DntR and NagR. The inducer respons

SUBMITTER: Lonneborg R 

PROVIDER: S-EPMC3180648 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature