Impact of aging vs. estrogen loss on cardiac gene expression: estrogen replacement and inflammation.

ABSTRACT: Despite an abundance of evidence to the contrary from animal studies, large clinical trials on humans have shown that estrogen administered to postmenopausal women increases the risk of cardiovascular disease. However, timing may be everything, as estrogen is often administered immediately after ovariectomy (Ovx) in animal studies, while estrogen administration in human studies occurred many years postmenopause. This study investigates the discrepancy by administering 17β-estradiol (E2) in a slow-release capsule to Norway Brown rats both immediately following Ovx and 9 wk post-Ovx (Late), and studying differences in gene expression between these two groups compared with age-matched Ovx and sham-operated animals. Two different types of microarray were used to analyze the left ventricles fro

SUBMITTER: Pechenino AS 

PROVIDER: S-EPMC3180739 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature