LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8.

ABSTRACT:

Rationale

Activation of liver X receptors (LXRs) inhibits the progression of atherosclerosis and promotes regression of existing lesions. In addition, LXRα levels are high in regressive plaques. Macrophage arginase 1 (Arg1) expression is inversely correlated with atherosclerosis progression and is markedly decreased in foam cells within the lesion.

Objective

To investigate LXRα regulation of Arg1 expression in cultured macrophages and atherosclerotic regressive lesions.

Methods and results

We found that Arg1 expression is enhanced in CD68+ cells from regressive versus progressive lesions in a murine aortic arch transplant model. In cultured macrophages, ligand-activated LXRα markedly enhances basal and interleukin-4-induced Arg1 mRNA and protein expression as well as

SUBMITTER: Pourcet B 

PROVIDER: S-EPMC3180895 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature