Serum amino acid levels as a biomarker for renal cell carcinoma.

ABSTRACT:

Purpose

Prognosis in renal cell carcinoma is dependent on tumor stage at presentation, with significant differences in survival between early and late stage disease. Currently to our knowledge no screening tests or biomarkers have been identified for the early detection of kidney cancer. Therefore, we investigated whether serum amino acid profiles are a potentially useful biomarker in patients with renal cell carcinoma.

Materials and methods

The concentrations of 26 amino acids were determined in serum taken preoperatively from 189 patients with renal cell carcinoma, and from 104 age and sex matched controls.

Results

Statistically significant changes were observed in patient levels of 15 amino acids, with 13 being decreased and 2 being increased. A logistic regression

SUBMITTER: Mustafa A 

PROVIDER: S-EPMC3180900 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature