Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis.

ABSTRACT:

Background

In contrast to tumor-suppressive apoptosis and autophagic cell death, necrosis promotes tumor progression by releasing the pro-inflammatory and tumor-promoting cytokine high mobility group box 1 (HMGB1), and its presence in tumor patients is associated with poor prognosis. Thus, necrosis has important clinical implications in tumor development; however, its molecular mechanism remains poorly understood.

Results

In the present study, we show that Distal-less 2 (Dlx-2), a homeobox gene of the Dlx family that is involved in embryonic development, is induced in cancer cell lines dependently of reactive oxygen species (ROS) in response to glucose deprivation (GD), one of the metabolic stresses occurring in solid tumors. Increased Dlx-2 expression was also detected in t

SUBMITTER: Lee SY 

PROVIDER: S-EPMC3181206 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature