MicroRNA regulation and tissue-specific protein interaction network.

ABSTRACT:

Background

'Fine-tuning' of protein abundance makes microRNAs (miRNAs) pervasively implicated in human biology. Although targeting many mRNAs endows the power of single miRNA to regulate complex biological processes, its functional roles in a particular tissue will be inevitably restricted because only a subset of its target genes is expressed.

Methods

Here, we analyze the characteristics of miRNA regulation upon target genes according to tissue-specific gene expression by constructing tissue-specific protein interaction networks for ten main types of tissues in the human body.

Results

Commonly expressed proteins are under more intensive but lower-cost miRNAs control than proteins with the tissue-specific expression. MiRNAs that target more commonly expressed genes us

SUBMITTER: Zhu W 

PROVIDER: S-EPMC3181334 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature