Predictors, moderators, and mediators (correlates) of treatment outcome in major depressive disorder.

ABSTRACT: Major Depressive Disorder (MDD) is a prevalent illness that is frequently associated with significant disability, morbidity and mortality Despite the development and availability of numerous treatment options for MDD, studies have shown that antidepressant monotherapy yields only modest rates of response and remission. Clearly, there is an urgent need to develop more effective treatment strategies for patients with MDD. One possible approach towards the development of novel pharmacotherapeutic strategies for MDD involves identifying subpopulations of depressed patients who are more likely to experience the benefits of a given (existing) treatment versus placebo, or versus a second treatment. Attempts have been made to identify such "subpopulations", specifically by testing whether a given

SUBMITTER: Papakostas GI 

PROVIDER: S-EPMC3181892 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature