Effect of folic acid supplementation on cardiovascular outcomes: a systematic review and meta-analysis.

ABSTRACT:

Background

Folic acid is widely used to lower homocysteine concentrations and prevent adverse cardiovascular outcomes. However, the effect of folic acid on cardiovascular events is not clear at the present time. We carried out a comprehensive systematic review and meta-analysis to assess the effects of folic acid supplementation on cardiovascular outcomes.

Methodology and principal findings

We systematically searched Medline, EmBase, the Cochrane Central Register of Controlled Trials, reference lists of articles, and proceedings of major meetings for relevant literature. We included randomized placebo-controlled trials that reported on the effects of folic acid on cardiovascular events compared to placebo. Of 1594 identified studies, we included 16 trials reporting data on 4

SUBMITTER: Zhou YH 

PROVIDER: S-EPMC3182189 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature