Classification and analysis of regulatory pathways using graph property, biochemical and physicochemical property, and functional property.

ABSTRACT: Given a regulatory pathway system consisting of a set of proteins, can we predict which pathway class it belongs to? Such a problem is closely related to the biological function of the pathway in cells and hence is quite fundamental and essential in systems biology and proteomics. This is also an extremely difficult and challenging problem due to its complexity. To address this problem, a novel approach was developed that can be used to predict query pathways among the following six functional categories: (i) "Metabolism", (ii) "Genetic Information Processing", (iii) "Environmental Information Processing", (iv) "Cellular Processes", (v) "Organismal Systems", and (vi) "Human Diseases". The prediction method was established trough the following procedures: (i) according to the general form o

SUBMITTER: Huang T 

PROVIDER: S-EPMC3182212 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature