Dynamics and mechanical stability of the developing dorsoventral organizer of the wing imaginal disc.

ABSTRACT: Shaping the primordia during development relies on forces and mechanisms able to control cell segregation. In the imaginal discs of Drosophila the cellular populations that will give rise to the dorsal and ventral parts on the wing blade are segregated and do not intermingle. A cellular population that becomes specified by the boundary of the dorsal and ventral cellular domains, the so-called organizer, controls this process. In this paper we study the dynamics and stability of the dorsal-ventral organizer of the wing imaginal disc of Drosophila as cell proliferation advances. Our approach is based on a vertex model to perform in silico experiments that are fully dynamical and take into account the available experimental data such as: cell packing properties, orientation of the cellular di

SUBMITTER: Canela-Xandri O 

PROVIDER: S-EPMC3182857 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature