Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections.

ABSTRACT: Here we have identified HIV-1 B clade Envelope (Env) amino acid signatures from early in infection that may be favored at transmission, as well as patterns of recurrent mutation in chronic infection that may reflect common pathways of immune evasion. To accomplish this, we compared thousands of sequences derived by single genome amplification from several hundred individuals that were sampled either early in infection or were chronically infected. Samples were divided at the outset into hypothesis-forming and validation sets, and we used phylogenetically corrected statistical strategies to identify signatures, systematically scanning all of Env. Signatures included single amino acids, glycosylation motifs, and multi-site patterns based on functional or structural groupings of amino acids.

SUBMITTER: Gnanakaran S 

PROVIDER: S-EPMC3182927 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature