Latency profiles of full length HIV-1 molecular clone variants with a subtype specific promoter.

ABSTRACT:

Background

HIV-1 transcription initiation depends on cellular transcription factors that bind to promoter sequences in the Long Terminal Repeat (LTR). Each HIV-1 subtype has a specific LTR promoter configuration and even minor sequence changes in the transcription factor binding sites (TFBS) or their arrangement can impact transcriptional activity. Most latency studies have focused on HIV-1 subtype B strains, and the degree to which LTR promoter variation contributes to differences in proviral latency is therefore largely unknown. Latency differences may influence establishment and size of viral reservoirs as well as the possibility to clear the virus by therapeutic intervention.

Results

We investigated the proviral transcriptional latency properties of different HIV-1 subty

SUBMITTER: van der Sluis RM 

PROVIDER: S-EPMC3182984 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature