Endocytosis is essential for dynamic translocation of a syntaxin 1 orthologue during fission yeast meiosis.

ABSTRACT: Syntaxin is a component of the target soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex, which is responsible for fusion of membrane vesicles at the target membrane. The fission yeast syntaxin 1 orthologue Psy1 is essential for both vegetative growth and spore formation. During meiosis, Psy1 disappears from the plasma membrane (PM) and dramatically relocalizes on the nascent forespore membrane, which becomes the PM of the spore. Here we report the molecular details and biological significance of Psy1 relocalization. We find that, immediately after meiosis I, Psy1 is selectively internalized by endocytosis. In addition, a meiosis-specific signal induced by the transcription factor Mei4 seems to trigger this internalization. The internalization of many PM proteins

SUBMITTER: Kashiwazaki J 

PROVIDER: S-EPMC3183020 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature