Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery.

ABSTRACT:

Objective

The aim of this study was to evaluate global gene expression patterns in the common iliac arteries of monkeys with a varied extent of atherosclerosis.

Methods

The left common iliac artery was removed from ovariectomized cynomolgus monkeys (n = 12) after 6.5 years of consuming a diet containing fat and cholesterol at levels comparable with those consumed in Western populations. Arterial gene expression was analyzed using DNA microarray and real-time reverse transcription-polymerase chain reaction.

Results

Significant differential expression of 986 genes was observed in iliac arteries containing moderate to large atherosclerotic plaques compared with normal/minimally affected reference group arteries. Atherosclerosis-associated genes included cytokines, chemok

SUBMITTER: Eyster KM 

PROVIDER: S-EPMC3183138 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature