Depression and incident stroke in women.

ABSTRACT:

Background and purpose

Depression has been associated with an increased risk of coronary heart disease, but prospective data for the association with stroke are limited.

Methods

We followed-up 80 574 women aged 54 to 79 years in Nurses' Health Study without a history of stroke from 2000 to 2006. Depressive symptoms were assessed at multiple time points by a Mental Health Index score (1992, 1996, and 2000), and clinical significant depressive symptoms were defined as a score≤52. Antidepressant medication use was asked biennially beginning in 1996, and physician-diagnosed depression was reported biennially beginning in 2000. Depression was defined as currently reporting or having a history of any of these 3 conditions.

Results

During 6 years of follow-up, 1033 incident

SUBMITTER: Pan A 

PROVIDER: S-EPMC3183155 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature