Metabolic adaptations to early life protein restriction differ by offspring sex and post-weaning diet in the mouse.

ABSTRACT:

Background and aims

Low birth weight affects 1 in every 7 babies born globally and can predict a lifetime of increased risk for adverse health outcomes, including cardiovascular disease, hypertension, obesity, diabetes, and metabolic syndrome. Maternal low protein diet during pregnancy and lactation is a well-characterized rat model for low birth weight and the subsequent increase in chronic disease risk. However, mice have been relatively understudied in this paradigm and represent a critical resource for investigating the underlying molecular mechanisms that link adverse early life experience and the development of chronic disease.

Methods and results

The present manuscript describes a mouse model of low birth weight (maternal consumption of low protein diet (8% protein) t

SUBMITTER: Whitaker KW 

PROVIDER: S-EPMC3183163 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature