Evidence for distinct histologic profile of nasal polyps with and without eosinophilia.

ABSTRACT:

Objective/hypothesis

To evaluate the histology, RNA, and protein signatures of nasal polyps (NPs) in order to demonstrate specific subtypes of disease and differentiate "idiopathic" NPs based on tissue eosinophilia.

Study design

Prospective laboratory-based study.

Methods

NP tissue was obtained from patients referred to the University of Virginia Health System for sinus surgery. Histology analyses included hematoxylin-eosin, Gomori's trichrome, toluidine blue, and chloroacetate staining. RNA and protein were extracted from tissue and cytokine transcript or protein concentrations determined.

Results

Idiopathic NPs can be divided into distinct subsets characterized by absence (NE) and presence (E) of prominent eosinophilia. The validity of this distinction is sup

SUBMITTER: Payne SC 

PROVIDER: S-EPMC3183261 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature