TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier.

ABSTRACT: The epidermal barrier varies over the body surface to accommodate regional environmental stresses. Regional skin barrier variation is produced by site-dependent epidermal differentiation from common keratinocyte precursors and often manifests as site-specific skin disease or irritation. There is strong evidence for body-site-dependent dermal programming of epidermal differentiation in which the epidermis responds by altering expression of key barrier proteins, but the underlying mechanisms have not been defined. The LCE multigene cluster encodes barrier proteins that are differentially expressed over the body surface, and perturbation of LCE cluster expression is linked to the common regional skin disease psoriasis. LCE subclusters comprise genes expressed variably in either external barri

SUBMITTER: Jackson B 

PROVIDER: S-EPMC3183491 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature