XMRV: usage of receptors and potential co-receptors.

ABSTRACT:

Background

XMRV is a gammaretrovirus first identified in prostate tissues of Prostate Cancer (PC) patients and later in the blood cells of patients with Chronic Fatigue Syndrome (CFS). Although XMRV is thought to use XPR1 for cell entry, it infects A549 cells that do not express XPR1, suggesting usage of other receptors or co-receptors.

Methods

To study the usage of different receptors and co- receptors that could play a role in XMRV infection of lymphoid cells and GHOST (GFP- Human osteosarcoma) cells expressing CD4 along with different chemokine receptors including CCR1, CCR2, etc., were infected with XMRV. Culture supernatants and cells were tested for XMRV replication using real time quantitative PCR.

Results

Infection and replication of XMRV was seen in a variety

SUBMITTER: Setty MK 

PROVIDER: S-EPMC3184104 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature