Association of membrane rafts and postsynaptic density: proteomics, biochemical, and ultrastructural analyses.

ABSTRACT: J. Neurochem. (2011) 119, 64-77.

Abstract

Postsynaptic membrane rafts are believed to play important roles in synaptic signaling, plasticity, and maintenance. However, their molecular identities remain elusive. Further, how they interact with the well-established signaling specialization, the postsynaptic density (PSD), is poorly understood. We previously detected a number of conventional PSD proteins in detergent-resistant membranes (DRMs). Here, we have performed liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) analyses on postsynaptic membrane rafts and PSDs. Our comparative analysis identified an extensive overlap of protein components in the two structures. This overlapping could be explained, at least partly, by a physical association of the two structure

SUBMITTER: Suzuki T 

PROVIDER: S-EPMC3184177 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature