Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes.

ABSTRACT:

Purpose

To test the hypothesis-given the increasing emphasis on quantitative computed tomographic (CT) phenotypes of chronic obstructive pulmonary disease (COPD)-that a relationship exists between COPD exacerbation frequency and quantitative CT measures of emphysema and airway disease.

Materials and methods

This research protocol was approved by the institutional review board of each participating institution, and all participants provided written informed consent. One thousand two subjects who were enrolled in the COPDGene Study and met the GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria for COPD with quantitative CT analysis were included. Total lung emphysema percentage was measured by using the attenuation mask technique with a -950-HU threshold. A

SUBMITTER: Han MK 

PROVIDER: S-EPMC3184233 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature