No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data.

ABSTRACT:

Background

The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a meta-analysis.

Methods

We conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently, we performed a meta-analysis of published genetic association studies by searching through Medline, PubMed and Web of Science databases.

Results

No significant differences were found in the distribution of alleles (χ2

SUBMITTER: Tovilla-Zarate C 

PROVIDER: S-EPMC3184265 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature