Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation.

ABSTRACT: Despite numerous observations of the effects of estrogens on spermatogenesis, identification of estrogen-regulated genes in the testis is limited. Using rats in which irradiation had completely blocked spermatogonial differentiation, we previously showed that testosterone suppression with gonadotropin-releasing hormone-antagonist acyline and the antiandrogen flutamide stimulated spermatogenic recovery and that addition of estradiol (E2) to this regimen accelerated this recovery. We report here the global changes in testicular cell gene expression induced by the E2 treatment. By minimizing the changes in other hormones and using concurrent data on regulation of the genes by these hormones, we were able to dissect the effects of estrogen on gene expression, independent of gonadotropin or tes

SUBMITTER: Zhou W 

PROVIDER: S-EPMC3184294 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature