Heterogeneous catalytic hydrogenation of unprotected indoles in water: a green solution to a long-standing challenge.

ABSTRACT: An environmentally benign procedure for the hydrogenation of unprotected indoles is described. The hydrogenation reaction is catalyzed by Pt/C and activated by p-toluenesulfonic acid in water as a solvent. The efficacy of the method is illustrated by the hydrogenation of a variety of substituted indoles to their corresponding indolines which were obtained in excellent yields.

SUBMITTER: Kulkarni A 

PROVIDER: S-EPMC3184324 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature