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Structural mass spectrometry of proteins using hydroxyl radical based protein footprinting.

ABSTRACT: Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described.

SUBMITTER: Wang L 

PROVIDER: S-EPMC3184339 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Structural mass spectrometry of proteins using hydroxyl radical based protein footprinting.

Wang Liwen L   Chance Mark R MR  

Analytical chemistry 20110801 19

Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described. ...[more]

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