Limitations of closing percutaneous transthoracic ventricular access ports using a commercial collagen vascular closure device.

ABSTRACT:

Introduction

Closed-chest access and closure of direct cardiac punctures may enable a range of therapeutic procedures. We evaluate the safety and feasibility of closing percutaneous direct ventricular access sites using a commercial collagen-based femoral artery closure device.

Methods

Yorkshire swine underwent percutaneous transthoracic left ventricular access (n = 13). The access port was closed using a commercial collagen-based vascular closure device (Angio-Seal, St. Jude Medical) with or without prior separation of the pericardial layers by instillation of fluid into the pericardial space ("permissive pericardial tamponade"). After initial nonsurvival feasibility experiments (n = 6); animals underwent 1-week (n = 3) or 6-week follow-up (n = 4).

Results

In naïve a

SUBMITTER: Barbash IM 

PROVIDER: S-EPMC3184403 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature