Recurrence of congenital heart disease in cases with familial risk screened prenatally by echocardiography.

ABSTRACT:

Objectives

To evaluate the recurrence of congenital heart disease (CHD) in pregnant women with familial risk who had been referred for fetal echocardiography.

Material and methods

1634 pregnancies from 1483 women with familial history of CHD in one or more relatives were studied. Fetal cardiologic diagnosis was compared with postnatal findings at 6 months or at autopsy.

Results

Total recurrence rate of CHD was 3.98%, 4.06% in single familial risk, 2.9% in double, and 5% in multiple risk. It was 3.5% in case of one previously affected child; 4.5% with 2 children; 5.2% with the mother alone affected and 7,5% with father alone affected and 3.5% with a single distant relative. Exact concordance of CHD was found in 21.5% and a partial concordance in 20% of cases.

Conclu

SUBMITTER: Fesslova V 

PROVIDER: S-EPMC3184425 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature