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Targeting the heat shock protein 90 dimer with dimeric inhibitors.

ABSTRACT: The design, synthesis, and biological evaluation of conformationally constrained coumermycin A1 analogues are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogues that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replacement of the stereochemically complex noviose sugar with readily available piperidine rings resulted in ?100 fold increase in antiproliferative activities as compared to coumermycin A1, producing small molecule Hsp90 inhibitors that exhibit nanomolar activities.

SUBMITTER: Kusuma BR 

PROVIDER: S-EPMC3184553 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Targeting the heat shock protein 90 dimer with dimeric inhibitors.

Kusuma Bhaskar Reddy BR   Peterson Laura B LB   Zhao Huiping H   Vielhauer George G   Holzbeierlein Jeffrey J   Blagg Brian S J BS  

Journal of medicinal chemistry 20110823 18

The design, synthesis, and biological evaluation of conformationally constrained coumermycin A1 analogues are reported. Compounds were evaluated against both breast cancer (SKBr3 and MCF7) and prostate cancer (PC3 mm2, A549, and HT29) cell lines. Non-noviosylated coumermycin A1 analogues that manifest potent antiproliferative activity resulting from Hsp90 inhibition are provided, wherein replacement of the stereochemically complex noviose sugar with readily available piperidine rings resulted in  ...[more]

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