Estimating treatment effects for individual patients based on the results of randomised clinical trials.

ABSTRACT:

Objectives

To predict treatment effects for individual patients based on data from randomised trials, taking rosuvastatin treatment in the primary prevention of cardiovascular disease as an example, and to evaluate the net benefit of making treatment decisions for individual patients based on a predicted absolute treatment effect.

Setting

As an example, data were used from the Justification for the Use of Statins in Prevention (JUPITER) trial, a randomised controlled trial evaluating the effect of rosuvastatin 20 mg daily versus placebo on the occurrence of cardiovascular events (myocardial infarction, stroke, arterial revascularisation, admission to hospital for unstable angina, or death from cardiovascular causes). Population 17,802 healthy men and women who had low densit

SUBMITTER: Dorresteijn JA 

PROVIDER: S-EPMC3184644 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature