Histone chaperones, histone acetylation, and the fluidity of the chromogenome.

ABSTRACT: The "chromogenome" is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post-translational acetylation of histones, and modulation of the chromogenome. We emphasize those chaperones that function in a replication-independent manner, and for which three-dimensional structural information has been obtained. The emerging links between histone acetylation and chaperone function in both yeast and higher metazoans are discussed, including the importance of nucleosome-free regions. We close by posing many questions pertaining to how the coupled action of histone chaperones and acetylation influences chromogenome structure and function.

SUBMITTER: Hansen JC 

PROVIDER: S-EPMC3184832 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature