CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome.

ABSTRACT:

Purpose

Polymorphisms of the cluster of differentiation 40 (CD40) gene have recently been identified to be associated with the risk to several immune diseases. The aim of this study was to determine the potential association of CD40 polymorphisms with Fuch uveitis syndrome (FUS).

Methods

A total of 131 Han Chinese patients with FUS and 402 healthy controls were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Genotype counts in patients and controls were analyzed by the χ(2) test.

Results

All genotypic and allelic frequencies of the tested two CD40 polymorphisms were in Hardy-Weinberg equilibrium. The genotypic and allelic frequencies of rs4810485 and rs1883832 were not different between patients with FUS and co

SUBMITTER: Chen F 

PROVIDER: S-EPMC3185045 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature