The subcellular distribution of small molecules: a meta-analysis.

ABSTRACT: To explore the extent to which current knowledge about the organelle-targeting features of small molecules may be applicable toward controlling the accumulation and distribution of exogenous chemical agents inside cells, molecules with known subcellular localization properties (as reported in the scientific literature) were compiled into a single data set. This data set was compared to a reference data set of approved drug molecules derived from the DrugBank database, and to a reference data set of random organic molecules derived from the PubChem database. Cheminformatic analysis revealed that molecules with reported subcellular localizations were comparably diverse. However, the calculated physicochemical properties of molecules reported to accumulate in different organelles were markedl

SUBMITTER: Zheng N 

PROVIDER: S-EPMC3185174 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature