Dietary weight loss and exercise effects on insulin resistance in postmenopausal women.

ABSTRACT:

Background

Comprehensive lifestyle interventions are effective in preventing diabetes and restoring glucose regulation; however, the key stimulus for change has not been identified and effects in older individuals are not established. The aim of the study was to investigate the independent and combined effects of dietary weight loss and exercise on insulin sensitivity and restoration of normal fasting glucose in middle-aged and older women.

Design

Four-arm RCT, conducted between 2005 and 2009 and data analyzed in 2010.

Setting/participants

439 inactive, overweight/obese postmenopausal women.

Interventions

Women were assigned to: dietary weight loss (n=118); exercise (n=117); exercise+diet (n=117); or control (n=87). The diet intervention was a group-based reduc

SUBMITTER: Mason C 

PROVIDER: S-EPMC3185302 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature