Internal standard-based analysis of microarray data2--analysis of functional associations between HVE-genes.

ABSTRACT: In this work we apply the Internal Standard-based analytical approach that we described in an earlier communication and here we demonstrate experimental results on functional associations among the hypervariably-expressed genes (HVE-genes). Our working assumption was that those genetic components, which initiate the disease, involve HVE-genes for which the level of expression is undistinguishable among healthy individuals and individuals with pathology. We show that analysis of the functional associations of the HVE-genes is indeed suitable to revealing disease-specific differences. We show also that another possible exploit of HVE-genes for characterization of pathological alterations is by using multivariate classification methods. This in turn offers important clues on naturally occurri

SUBMITTER: Dozmorov IM 

PROVIDER: S-EPMC3185418 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature