Poxvirus exploitation of the ubiquitin-proteasome system.

ABSTRACT: Ubiquitination plays a critical role in many cellular processes. A growing number of viruses have evolved strategies to exploit the ubiquitin-proteasome system, including members of the Poxviridae family. Members of the poxvirus family have recently been shown to encode BTB/kelch and ankyrin/F-box proteins that interact with cullin-3 and cullin-1 based ubiquitin ligases, respectively. Multiple members of the poxvirus family also encode ubiquitin ligases with intrinsic activity. This review describes the numerous mechanisms that poxviruses employ to manipulate the ubiquitin-proteasome system.

SUBMITTER: Barry M 

PROVIDER: S-EPMC3185573 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature