High levels of circulating CD34+ cells at autologous stem cell collection are associated with favourable prognosis in multiple myeloma.

ABSTRACT:

Background

High-dose chemotherapy with autologous stem cell transplantation is a cornerstone in the first-line treatment of multiple myeloma patients. However, only few factors have been identified affecting the outcome in such patients. We hypothesised that varying levels of mobilised CD34+ cells confer prognostic information in myeloma patients undergoing high-dose chemotherapy.

Methods

We determined circulating CD34+ cells at the day of peripheral stem cell collection in 158 consecutive myeloma patients between January 2001 and August 2010. Patients were stratified into two groups (super vs normal mobilisers) with a cutoff of 100,000 peripheral CD34+ cells per ml.

Results

We found that patients with more than 100,000 peripheral CD34+ cells per ml had a better overa

SUBMITTER: Raschle J 

PROVIDER: S-EPMC3185945 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature