Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions.

ABSTRACT: Guanine (G) rich G(4)T(4)G(4) DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5'-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by pi-pi-stacking interaction exerted by the 5'-residues.

SUBMITTER: Saha S 

PROVIDER: S-EPMC3186060 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature