Published and perished? The influence of the searched protein database on the long-term storage of proteomics data.

ABSTRACT: In proteomics, protein identifications are reported and stored using an unstable reference system: protein identifiers. These proprietary identifiers are created individually by every protein database and can change or may even be deleted over time. To estimate the effect of the searched protein sequence database on the long-term storage of proteomics data we analyzed the changes of reported protein identifiers from all public experiments in the Proteomics Identifications (PRIDE) database by November 2010. To map the submitted protein identifier to a currently active entry, two distinct approaches were used. The first approach used the Protein Identifier Cross Referencing (PICR) service at the EBI, which maps protein identifiers based on 100% sequence identity. The second one (called logic

SUBMITTER: Griss J 

PROVIDER: S-EPMC3186200 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature