A major effect quantitative trait locus for whirling disease resistance identified in rainbow trout (Oncorhynchus mykiss).

ABSTRACT: Whirling disease, caused by the pathogen Myxobolus cerebralis, leads to skeletal deformation, neurological impairment and under certain conditions, mortality of juvenile salmonid fishes. The disease has impacted the propagation and survival of many salmonid species over six continents, with particularly negative consequences for rainbow trout. To assess the genetic basis of whirling disease resistance in rainbow trout, genome-wide mapping was initiated using a large outbred F(2) rainbow trout family (n=480) and results were confirmed in three additional outbred F(2) families (n=96 per family). A single quantitative trait locus (QTL) region on chromosome Omy9 was identified in the large mapping family and confirmed in all additional families. This region explains 50-86% of the phenotypic va

SUBMITTER: Baerwald MR 

PROVIDER: S-EPMC3186244 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature