Extensive pancreas regeneration following acinar-specific disruption of Xbp1 in mice.

ABSTRACT:

Background & aims

Progression of diseases of the exocrine pancreas, which include pancreatitis and cancer, is associated with increased levels of cell stress. Pancreatic acinar cells are involved in development of these diseases and, because of their high level of protein output, they require an efficient, unfolded protein response (UPR) that mediates recovery from endoplasmic reticulum (ER) stress following the accumulation of misfolded proteins.

Methods

To study recovery from ER stress in the exocrine organ, we generated mice with conditional disruption of Xbp1 (a principal component of the UPR) in most adult pancreatic acinar cells (Xbp1fl/fl). We monitored the effects of constitutive ER stress in the exocrine pancreas of these mice.

Results

Xbp1-null acinar cells

SUBMITTER: Hess DA 

PROVIDER: S-EPMC3186847 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature