A screening assay based on host-pathogen interaction models identifies a set of novel antifungal benzimidazole derivatives.

ABSTRACT: Fungal infections are a serious health problem in clinics, especially in the immune-compromised patient. Disease ranges from widespread superficial infections like vulvovaginal infections to life-threatening systemic candidiasis. Especially for systemic mycoses, only a limited arsenal of antifungals is available. The most commonly used classes of antifungal compounds used include azoles, polyenes, and echinocandins. Due to emerging resistance to standard therapy, significant side effects, and high costs for several antifungals, there is a medical need for new antifungals in the clinic and general practice. In order to expand the arsenal of compounds with antifungal activities, we screened a compound library including more than 35,000 individual compounds derived from organic synthesis as w

SUBMITTER: Burger-Kentischer A 

PROVIDER: S-EPMC3186968 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature