First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM.

ABSTRACT: Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.

SUBMITTER: Bador J 

PROVIDER: S-EPMC3186983 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature