Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt.

ABSTRACT: Viruses commonly use host cell survival mechanisms to their own advantage. We show that Akt, an important signaling kinase involved in cell survival, phosphorylates the RNA-dependent RNA polymerase (RdRp) from norovirus, the major cause of gastroenteritis outbreaks worldwide. The Akt phosphorylation of RdRp appears to be a feature unique to the more prevalent norovirus genotypes such as GII.4 and GII.b. This phosphorylation event occurs at a residue (Thr33) located at the interface where the RdRp finger and thumb domains interact and decreases de novo activity of the polymerase. This finding provides fresh insights into virus-host cell interactions.

SUBMITTER: Eden JS 

PROVIDER: S-EPMC3187498 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature