Integration of SNP genotyping confidence scores in IBD inference.

ABSTRACT:

Motivation

High-throughput single nucleotide polymorphism (SNP) arrays have become the standard platform for linkage and association analyses. The high SNP density of these platforms allows high-resolution identification of ancestral recombination events even for distant relatives many generations apart. However, such inference is sensitive to marker mistyping and current error detection methods rely on the genotyping of additional close relatives. Genotyping algorithms provide a confidence score for each marker call that is currently not integrated in existing methods. There is a need for a model that incorporates this prior information within the standard identical by descent (IBD) and association analyses.

Results

We propose a novel model that incorporates marker confiden

SUBMITTER: Markus B 

PROVIDER: S-EPMC3187655 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature